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29 Bioavailability of IGFs is regulated by a class of six IGF-binding proteins (IGFBP-16), which are also produced in the liver

In the study by Mehta et al (Mehta A), children with congenital isolated GH deficiency demonstrated growth retardation as already at 6 months of age (26 10 SD and 22 13 SD in weight and length, respectively) prior to starting treatment

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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Ozempic, Rybelsus) and chronic weight management (Wegovy)