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E3 ligases in metabolic diseases Insulin receptors and insulin receptor substrates (IRS-1 and IRS-2) are crucial for insulin signaling, and E3 ligases such as MG53, c-Cbl, and Nedd4 can directly degrade these substrates, disrupting signaling and promoting insulin resistance

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The power of this code lies in its capacity to integrate diverse stimuli and mediate cross-talk between distinct death modalities

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