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Oxidative stress and mitochondrial dysfunction in sepsis: a potential therapy with mitochondria-targeted antioxidants

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When Ang II binds to AT1R, it triggers the activation of the JNK and ERK signaling pathways, leading to upregulated expression of early growth response factor 1 (Egr-1), which results in vasoconstriction, inflammation, oxidative stress, and increased expression of ICAM-1 and vascular cell adhesion molecule-1 (VCAM-1)

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The concentrations of neurobiological markers in supernatants were assessed by enzyme-linked immunosorbent assay (ELISA Kits for mice: GFAP, NEFL, NSE, and GAL3