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hdl:2292/34799

ClinicalTrials.gov ID: NCT05732051

Swantek, J

Firstly, different cancer cell lines may exhibit varying sensitivity to iron dependent death

Researchers must also generate non-clinical evidence demonstrating that the compound interacts with the intended target and produces the expected pharmacological effects without showing major safety concerns

This was evident from the decreased levels of markers that indicate cellular damage caused by oxidative stress, and the protective effects of 3AB were attributed to the increased activity of Nrf2, a protein involved in regulating antioxidant defenses, and GCLC, an enzyme responsible for synthesizing glutathione, a potent antioxidant