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Nat Med 2 : 12541258

Introduction Type 2 diabetes (T2D) is one of the major health concerns affecting 9% of the global population, putting those affected at risk of cardiovascular-associated mortality ( The incretins glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are peptide hormones secreted from intestinal enteroendocrine cells (Nauck and Meier, 2018), with the incretin effect referring to the greater amount of insulin secreted in response to an oral glucose load relative to an equal intravenous dose

doi: 10.1016/j.neuropharm.2020.108042 242 WangZJHanYFZhaoFYangGZYuanLCaiHYet al

10.1007/s00125-023-05973-w 78 SoresiM.GiannitrapaniL

They tend to be more effective because they bypass the digestive system, ensuring a higher concentration of the active drug reaches the bloodstream. GLP-1 pills have to battle stomach acid Of course, studies have shown that weight loss is a direct result of GLP-1 pills

The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test