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Ineffective neutralization of overmuch ROS could result in serious pathophysiology including cancer

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But how could extracellular GSH even be doing anything if most data suggest that cells do not take up GSH

These include prolonged immobility, recent surgery, active cancer, pregnancy, use of combined hormonal contraceptives or hormone replacement therapy, previous history of blood clots, inherited thrombophilias, obesity, smoking, and increasing age