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The DEGs were significantly enriched in metabolic pathways, protein digestion and absorption, retinol metabolism, MAPK signaling pathway, PI3KAkt signaling pathway, Wnt signaling pathway, PPAR signaling pathway, and TGF-beta signaling pathway (Figure 4A)

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Potential off-target effects: broad changes to methylation could, in theory, affect gene expression in ways not yet characterised

Consequently, regarding the formation of multidrug resistance in tumor cells, besides acting as a detoxification enzyme though excretion of drugs to decrease pharmacological efficacy, GST can also act as an MAPK-pathway inhibitor to improve tumor-cell survival

It is a fat-soluble compound that can span the entire cell membrane

Eating disorders associated with overweight and obesity Eating disorders are prevalent among individuals with a body mass index (BMI) in the range of overweight or obesity, with BED being the most common