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Loss of FBP1 not only sustains elevated glycolytic flux, but also destabilizes the mitochondrial membrane potential, increases ROS levels, and impairs activation of antioxidant defenses such as SOD2 [99]

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When attending an appointment, it helps to come prepared

Common adverse effects include nausea, vomiting, diarrhea, constipation, and abdominal pain, which typically diminish over time as the body adjusts to treatment

No medications for overweight and obesity are currently subsidised by the PBS

Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation