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1 mM caffeine (Sigma, C1778 in PBS (pH 7.4) with 1% DMSO-d6) was used as a standard to quantify the ligand signals and determine the concentration of samples

Knight R, Khondoker M, Magill N, Stewart R, Landau S

These clots can break off and lodge in the blood vessels in the lungs, potentially causing death

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Third, although existing studies consistently demonstrate beneficial effects on hepatic steatosis and inflammation, the lack of head-to-head mechanistic and biomarker-based comparisons restricts the ability to distinguish between different GLP-1RAs or combination therapies in terms of their molecular pathways, immunemetabolic regulatory efficiency, and predictive biomarkers of therapeutic response

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