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Neuroglial changes in physiological brain ageing are relatively subtle, with white matter being the most affected: in healthy old age, white matter volume is decreased by ~ 10%, whereas the grey matter is reduced by a mere 3%

Published trial averages: Semaglutide: ~1015% of body weight Tirzepatide: ~1522% of body weight A typical arc: minimal change during early titration, a steadier phase over the following months, then a maintenance phase

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Although neurofibromas are benign tumors, plexiform neurofibromas may progress to malignant peripheral nerve sheath tumors