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Figure 1 3.2 Nicotine-related differentially expressed genes were linked to immune remodeling in COPD After intersecting COPD-related DEGs identified from the GSE57148 discovery cohort with the nicotine-related target set, the retained genes showed a disease-associated expression pattern in this cohort

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In particular, genetic defects in the Toll Like Receptor 3 (TLR3) signaling pathway that attenuate the type I interferon response to HSV are being increasingly recognized in children with severe phenotypes of HSV

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Most MS patients, over time and aging, switch to a progressive phase characterized by a gradual clinical decline with progressive deterioration of neurological functions, due to continuous axonal degeneration (Filippi et al., 2018)

Neither the participants nor the investigators were aware of the treatment allocation