As reported, Astrocytes and microglia can exert vital functions in PD, such as nourishing nerve cells, promoting neural signal transmission, and most importantly triggering neuroinflammation [5]
(140) found that post-operative IF reduced oxidative stress in the hippocampus of 2VO rats, as evidenced by decreased MDA concentration and reduced mRNA and protein levels of the reactive oxygen-generating enzyme NADPH oxidase 1
PTPN22 plays a key role in regulating T cell responses, and its variants are linked to a higher susceptibility to autoimmune disorders, emphasizing the role of immune dysregulation in DILI mechanisms [80]
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GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists
