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10.1016/j.biomaterials.2020.120278 82 ZhangM.GuoX.WangM.LiuK
The requirement of two distinct glutathione interaction sites for the efficient reduction of GSSR by GSH explains the deviating properties and substrate preferences of glutaredoxin subfamilies as well as thioredoxins with implications for the design and optimization of artificial enzymes and inhibitors
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GSH replenishment in human tissues is difficult due to its shorter half-life, and not easy to penetrate the plasma membrane hence use of prodrugs/precursors such as cysteine, and glycine is the most promising approach 4,45
RajaKhan N, Agito K, Shah J, et al