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Reference: Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells (2021)

Developmental expression of receptors for insulin, insulin-like growth factor I (IGF-I), and IGF-II in rat skeletal muscle

N 5 N 10 -Methylenetetrahydrofolate Synthesis N 5 , N 10 -methylene-THF (5,10-methylene-THF) is synthesized from THF and serine by the serine/glycine hydroxymethyltransferases (SHMT1 and SHMT2)

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Why this matters: Higher nerve density - The inner thigh has more nerves, making injections more painful Blood vessel proximity - The femoral artery and vein run through this area, increasing bleeding risk Variable fat depth - Subcutaneous tissue is less consistent here, raising the chance of injecting into muscle Clinical guidance from major medical centres is explicit: Do NOT use the inner thigh. Stick to the front and slightly outer aspect of your upper thigh, roughly the upper third of the leg

MDR1, Multidrug Resistance 1