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The only covariates with SMDs above the minimum threshold of 0.2 were inclusion year, diabetes duration, obesity, and previous use of DPP-4is, GLP-1 RAs, insulins, and sulfonylureas

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doi: 10.1155/2017/4015874

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Regulators also consider adverse events, trial design, patient selection, manufacturing consistency, and how the medicine would be used outside controlled studies