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Lixisenatide is an older drug in the same class as Novo Nordisks big-selling Ozempic/Wegovy (semaglutide), used to treat type 2 diabetes and obesity, as well as to reduce the risk of cardiovascular disease in some overweight patients

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In vivo experiments have shown that mice on a high-fat diet (HFD) treated with liraglutide displayed reduced concentrations of pro-inflammatory cytokines, such as interferon-gamma (IFN-) and IL-17, IL-22

After supplementation with DHO or OA (the substrate and product of DHODH), the ferroptosis caused by GPX4 inhibition was attenuated and enhanced, respectively, and these effects were particularly significant in cancer cells with low GPX4 expression