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Mechanisms of Collagen Synthesis The collagen synthesis mechanisms involve several key pathways: MAPK/ERK Pathway Activation This pathway upregulates collagen gene expression and promotes fibroblast proliferation, creating the cellular foundation for tissue repair

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For this reason, we encourage our patients to achieve a body mass index (BMI) of less than 35, and if possible, less than 30

doi:10.1186/1471-2172-13-32