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Diabetes Obes Metab 2019;21:18717.ArticlePubMedPDF 8

A 2025 network meta-analysis ranked nausea risk as follows: orforglipron (highest, relative risk 4.77), liraglutide (3.09), semaglutide (2.94), tirzepatide (2.89), exenatide (2.66), and cagrilintide (2.29)

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The phase 2 study specifically measured cravings and found significant reductions in desire for sweet foods (as early as week 4), salty foods (by week 16), and fatty foods (by weeks 12-16) at doses of 4mg and above compared to placebo

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