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The reasons for the wide-spread use of this test are the ease of performing the single intervention, the reproducible and spontaneous pain-related responses that can be observed in unrestrained animals, and finally, the 2 separately interpretable readouts

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Cummins DL, Cummins JM, Pantle H, et al., editors

observed that alcohol consumption causes neuronal injury in the hippocampal and prefrontal cortex of mice