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Patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) accumulate hepatic copper even without exogenous copper supplementation [7]

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Combined E1A gene therapy and taxol in HER-2/neu-overexpressing ovarian cancer: E1A chemosensitization through apoptosis involving caspase-3 pathway

It has been reported that by inhibiting phosphorylation of serine 10 in this pathway, breast cancer cells simultaneously challenged with estradiol show an overproduction of ROS, with increased oxidation of the DNA that overwhelms the repair apparatus and triggers PCD in a great percentage of these cells 144 (Fig