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Teff in MS patients' peripheral blood exhibit particular resistance to Treg cell-mediated suppression, further exacerbating immune imbalance (162, 169, 170)
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GLP-1 receptor agonists have been shown to reduce major adverse cardiovascular events including cardiovascular death, heart attack, and stroke in patients with type 2 diabetes
102,189,320,330 In patients with lower eGFR levels, uricosuric agents may not be as effective, necessitating the use of alternative agents with different mechanisms of action
Sensitivity tests Before PSM, the analysis of the crude populations showed consistent findings, indicating that GLP-1RA plus SGLT2i was associated with the primary composite outcome and individual outcomes compared to SGLT2i alone (Supplementary Table 4)