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Phenytoin is a potent inducer of CYP 2C9, 2C19, and 3A4, resulting in innumerable drug-drug interactions.(34300194) interactions between phenytoin and valproate Effect on phenytoin: Valproate inhibits CYP2C9, resulting in the accumulation of phenytoin

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In this paper, we report five cryo-EM structures of two well-recognized multi-targeting agonists (tirzepatide and peptide 20) in complex with individual receptors and G s proteins