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Thus, the strong acidic concentration used by Watt, McLean, and Marcus (1979 Watt, J., C

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Figure 2 2.1 Depletion of M2 TAMs Macrophages account for 60% of the cellular components in the tumor, and with the progression of the tumor the macrophages in TME are dominated by M2 TAMs which promote tumorigenesis and metastasis, and based on this reducing M2 TAMs in TME can eliminate the pro-tumor effects of macrophages (13)

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