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This represents one of the most advanced body recomposition protocols currently being explored in Canada and other countries

They operate under FDA oversight through either 503A (state-licensed) or 503B (outsourcing facility) designations

However, severe or progressive symptoms require immediate evaluation

The STEP 5 data suggests that ongoing administration is necessary to maintain results, as participants who discontinued semaglutide in the STEP 1 extension study regained approximately two-thirds of the weight they had lost within one year of stopping

Seven of these trials are expected to report results in 2026

Those relationships are better characterised than anything in the GLP-1 dermatology literature