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Most patients report minimal discomforttypically described as a mild pinch lasting secondsmaking it one of the least painful self-administered weekly medical injections available

One important note: intense exercise can temporarily increase inflammation in Hashimoto's patients

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In Sjgren's syndrome, DAMPs released from damaged salivary gland epithelial cells initiate inflammatory and autoimmune responses, resulting in a vicious autoimmune cycle [252, 335]

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