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Most xenobiotics undergo hepatic biotransformation via the CYP450 system, generating reactive intermediates that may form protein adducts or stimulate excessive production of reactive oxygen species (ROS), triggering downstream events like lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress that collectively led to hepatocellular damage (Jaeschke et al., 2012

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Sadgrove NJ, Simmonds MSJ

Jan-Feb 2023;76:91-98

( d ) Left: cell count as a percentage of the total per cluster per genotype, right: cell count per slice per cluster per genotype (GnasWT: n = 1,129 cells, 5 slices, 3 mice, 2 males

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