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Collagen and Elastin Production Collagen levels decline naturally with age, resulting in skin that is thinner and less resilient

Lipo-toxicity occurs when adipose tissue accumulates in non-fat organs (e.g., liver, pancreas, and muscle tissue), dysfunctionalizing organelles, releasing excess ROS, leading to systemic inflammation and IR [116]

Versantvoort CH, Broxterman HJ, Bagrij T, Scheper RJ, Twentyman PR

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Reasonable candidates are patients already engaged in a supervised weight-loss programme with diet and activity in place, who understand it is adjunctive

[DOI] [PubMed] [Google Scholar] 240.Sawicka AK, Renzi G, Olek RA