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The lactam bridge between Asp5 and Lys10 side chains cyclises the heptapeptide backbone and constraining it into a compact, conformationally rigid structure that stabilises the receptor-binding pharmacophore conformation required for high-affinity MC3R and MC4R engagement

An alternate version called Rybelsus was approved in September 2019, also as a Type 2 diabetes treatment, and semaglutide received approval for weight loss in June 2021 under the brand name Wegovy

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Commun 2016, 52 (95), 1379513798

(12) found that anthraquinone laxative can enhance cell proliferation activity, inhibit cell apoptosis, and may promote cell carcinogenesis