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Dermatologic Surgery Journal: Caffeine reduces vascular visibility and puffiness under eyes

Commonly discussed approaches include: Beginning with lower-dose usage Waiting several days before intentional UV exposure Introducing short sun or UV sessions gradually Reducing usage frequency once desired pigmentation develops Many users wait approximately 7 days before intentional sun exposure, particularly when beginning with lower dosages

The underlying mechanisms may involve the interplay of direct viral invasion of the central nervous system, immune dysregulation and neuroinflammation, vascular dysfunction, HPA axis dysregulation, and psychosocial stress

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[DOI] [PMC free article] [PubMed] [Google Scholar] 70.Shmelev A., Abdo A., Sachdev S., Shah U., Kowdley G.C., Cunningham S.C