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It plays a crucial role in muscle and nerve function, blood sugar regulation, and energy production
This reaction leads to the generation of a significant amount of lipid reactive oxygen species (ROS), contributing to the cellular demise that is characteristic of ferroptosis
In the Walsh framework, toxic overload is one biochemical pattern that may coexist with undermethylation, copper imbalance, pyroluria or other contributors
When assumptions of normality or homogeneity of variance were not met according to the Shapiro-Wilks or Brown-Forsythe test, respectively, KruskalWallis ANOVA and Dunns multiple comparison test were used
The complex binds copper through the N-terminal amine, the imidazole nitrogen of histidine, and the deprotonated amide nitrogen of the Gly-His peptide bond, forming a stable square-planar coordination geometry