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Informed consent was obtained from all the subjects prior to participation in the study

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L-2-HGA-associated genetic variants inhibit the activity of L-2hydroxyglutaric acid dehydrogenase (L2HGDH), an important mitochondrial enzyme involved in the metabolic processes of glutamate and glutamine, which oxidizes the L-2-hydroxyglutarate into -ketoglutarate [46] (Fig

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