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Whittle and R

Gut microbiota of patients with type 2 diabetes and gastrointestinal intolerance to metformin differs in composition and functionality from tolerant patients

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doi: 10.1097/MJT.0b013e318195e460

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In contrast, taking glutathione by mouth (as pills or liquids) is far less efficient because the compound is largely broken down in the gut before it ever reaches the cells