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Note: People taking an investigational 50-mg dose of Rybelsus reached an average of 15% of body weight lost over 68 weeks, though this dose isnt yet FDA-approved or available

Tirzepatide is part of a new group of drugs called dual incretin receptor agonists

Simplification of regimens is a competitive advantage: A growing share of patients, both commercial and Medicare, are managing diabetes with GLP1s or SGLT2s alone

doi:10.3390/nu16172886

Semaglutide for managing overweight and obesity TA875 Recommendations

But they also represent one of the most significant cost risks to employer health insurance plans heading into the 2026 renewal cycle