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Peri-Menopause and Menopause: A Natural Transition Peri-menopause typically begins in a womans late 30s to early 40s, and menopause officially starts when a woman has not had a menstrual period for 12 consecutive months

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Special Conditions Require Attention- Those with specific conditions such as eye problems, Lebers disease, kidney or liver disease, iron or folic acid deficiency, infections, or undergoing bone marrow-affecting treatments should seek professional advice

While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision

Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins