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The decision to use both medications concurrently should involve shared decision-making between the patient and healthcare provider, with clear discussion of: The therapeutic rationale for each medication Potential benefits and risks of concurrent use Alternative treatment options The importance of monitoring and follow-up Dose optimisation is crucial when using both medications together

Front Physiol (2016) 7:206

K., and Kumar, A

A randomized controlled trial (RCT) demonstrated that after 6 months of supplementation with 1.2 g/d of EPA + DHA for patients with knee OA, the WOMAC pain score decreased by 23% ( p = 0.02), and the synovial inflammation assessed by MRI was relieved (42)

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