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Gut microbiota disorder, gut epithelial and bloodbrain barrier dysfunctions in etiopathogenesis of dementia: molecular mechanisms and signaling pathways

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Cagrilintide in the Broader Peptide Landscape The metabolic peptide field has expanded dramatically, with various compounds targeting different aspects of metabolism: GLP-1 agonists (semaglutide, liraglutide) Single incretin pathway Dual agonists (tirzepatide) GIP + GLP-1 pathways Amylin analogues (cagrilintide) Amylin pathway Triple agonists (retatrutide) GIP + GLP-1 + Glucagon Metabolic modulators (5-Amino-1MQ) NNMT inhibition Each class offers unique mechanisms and potential applications in metabolic research

& Huffman, J