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Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)

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Contributing to free intracellular calcium levels is the release of calcium stored in the endoplasmic reticulum (ER) via the activation of calcium-activated calcium release channels, specifically the type 2 ryanodine receptor (RYR2)

For this purpose, 50 mg/kg thiopental sodium via IP was administered to the rats, and after vestibulocochlear nerve tissues were removed from the animals, and oxidant (MDA) and antioxidant (tGSH, SOD, and CAT) parameters were studied in tissues