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Studies have shown that, the fentanyl molecule occupies a "Y"-shaped conformation in the orthosteric pocket, and contacts mainly with residues from TM2, TM3, TM6, and TM7 of transmembrane domain (TMD)

According to FDA prescribing information, these include nausea (12-24%), diarrhea (7-23%), decreased appetite (10-19%), vomiting (2-11%), constipation (5-17%), and dyspepsia (5-9%), with rates varying by dose and indication

Factors such as genetics, lifestyle, and overall health play a significant role

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