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These microbial shifts trigger cascading gutbrain disruption by impairing neurotransmitter signaling, suppressing SCFA production, weakening epithelial barrier integrity, and activating neuroimmune pathways, ultimately resulting in anxiety- and depression-like behaviors in rodent models (Tejkalov et al., 2023

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Therefore, the targeted identification and management of key metabolic, infectious, inflammatory, hormonal, and toxic biomarkers (Table 4) is essential to obtain a clear picture of the specific dysfunctions and alterations present in each individual, with the aim of restoring homeostasis and addressing the aggressors that may represent the true drivers of the underlying pathophysiology

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67 , e2200450 (2023)