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In response to these comments, we have increased burden estimates, and as addressed above, have allowed additional flexibility to use an alternative, equivalent source of remittance data to address those concerns

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2) Most of the skin data is still prelinical (cell and animal studies) and human clinical trials are still limited

Similar findings strengthen our observation where SeNP specially dopped with plant residue recorded a downregulation of ROS generation in rice under Al stress [75]