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How It Works GHK-Cu Topical Cream (0.5%) FAQ Wisp Care Team GHK-Cu is a copper peptide your body naturally produces, but levels decline significantly with age

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Zeevi K, Volanek , Katsiki N, et al

This is often due to technique, local histamine response, or irritant effects from reconstitution practices

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease

PCR primers for each gene are listed in Supplementary Table 3