Ozempic, (generic name, Semaglutide) is a long-lasting glucagon-like peptide-1 receptor agonist (GLP-1 RA), originally developed to treat type 2 diabetes that has gone on to be dubbed the must-have, miracle weight loss drug, now also licensed in the UK for obesity as Wegovy
Therefore, Ang II can be formed locally in different vascular beds and can exert biological effects independent of blood-borne Ang II
A B12 shot is a quick intramuscular injection of vitamin B12 (cobalamin) that bypasses the stomach acid, liver metabolism, and intestinal absorption issues that limit oral B12 to roughly 1% bioavailability in most adults
The natriuretic effect of GLP-1RAs may also be partially attributed to a reduction of the activity of the reninangiotensinaldosterone system, as in clinical studies, GLP-1 and GLP-1RAs have been found to lower circulating angiotensin II levels by approximately 20% [24, 25]
These drugs are also being studied for their impact on Alzheimers disease and substance addictions due to their interactions with the brain
Besonders spannend ist jedoch der dritte Effekt: Die Magenentleerung wird verlangsamt, was in der Praxis bedeutet, dass wir uns schneller satt fhlen und deutlich weniger Nahrung bentigen, um dieses Sttigungsgefhl zu erreichen
