Once one or more of these protective mechanisms are compromised, bacteria or their products such as endotoxins (lipopolysaccharides, LPS) may breach the intestinal epithelium and disseminate to mesenteric lymph nodes and even distant organs like liver and lungs
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LPS activates TLR4 on microglia, leading to the release of inflammatory cytokines and chemokines (322), and promotes neuronal apoptosis and endothelial cells damage (323, 324)
Conclusion The maintenance of carnitine homeostasis is crucial for cell life in physiological and pathological conditions in which FAO occurs at a high rate