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Two substances can be used during one visit without being physically mixed together

Under the action of unhealthy metabolic factors (obesity, diabetes), ER stress is initiated, and IRE-1 is activated, which in turn leads to the phosphorylation of IRS1 at the serine 307 residue by activating JNK, thereby impairing insulin signaling

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doi: 10.1016/j.bbih.2020.100116 98 SeoS-KKwonB