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Effective for A rare seizure disorder that requires vitamin B6

Concurrent dosing reduces efficacy by creating NAD+ demand spikes and competitive receptor saturationtiming separation is the critical variable for synergy

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This is consistent with the methyl folate trap hypothesis (54), which predicts that, in vitamin B-12 deficiency, the inhibition of DNA synthesis and cell proliferation is removed upon administration of high doses of folic acid because of increased availability of nonmethylated folate

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