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Individual responses to timing vary considerably, and there is no clinical evidence that nighttime administration reduces gastrointestinal side effects compared to other times of day

However, most patients experience appetite suppression within 1-4 weeks, and weight loss starts after 4 weeks

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PLoS ONE 17(12):e0277692 Karamese SA, Gelen V, Yildiz GN, Albayrak K, Gedikli S, Kara A et al (2025) Investigation of the anti-inflammatory, anti-oxidant and anti-apoptotic activity of 18-glycyrrhetinic-acid on the model of LPS-induced lung injury in rats

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PAX4 gene transfer induces -to- cell phenotypic conversion and confers therapeutic benefits for diabetes treatment