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Here we describe some of the most characterized examples: Ethacrynic acid and analogues Ethacrynic acid (EA)an ,-unsaturated ketone used as diuretic drugis a common substrate/inhibitor of several GSTs (Fig

Mechanism-Based Inhibition of Human Steroid 5-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADPDihydrofinasteride, a Potent Bisubstrate Analog Inhibitor.J.Amer.Chem.Soc.1996,118, 2359-2365 78

With proper care, effects can last several months

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