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One reason could be that in vivo-studies are much more expensive and sophisticated

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These timelines represent general patterns rather than guarantees

That's because most zinc is stored inside cells, and levels of zinc in the plasma or serum are influenced by factors unrelated to depletion, such as recent meals, time of day, muscle breakdown during weight loss, and inflammation

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The mechanism is hypothesized to be similar to the intracellular process that leads to neuronal damage in Alzheimers disease