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Statements Acknowledgments Financial support from the Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) to AMC-R (grant 302352/2014-7) is gratefully achnowledged

Microbial metabolites such as SCFAs and tryptophan catabolites can influence brain function directly or via modulation of systemic inflammation

This consideration exists independently of GLP-1 use and should be discussed with a physician

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

Cigarette smoke, along with air pollution, other carcinogens, and random mutation, can change some of the DNA in these genes and make cells cancerous

Semaglutide, the active ingredient, mimics the actions of the naturally occurring hormone GLP-1