GSH inhibits PSC activation induced by high glucose via the ROS/TGF/SMAD pathway in vitro The above results indicated an increase in pancreatic fibrosis in rats treated with LOsG, which was accompanied by an increase in ROS/TGF/SMAD signalling, and PSC proliferation and activation, which were all prevented by GSH
While significant progress has been made in the use of liposomal nanoparticles for siRNA delivery in cancers, the application of these nanoparticles to deliver PGC-1 siRNA in bladder cancer remains underexplored, and the specific role of PGC-1 requires further investigation
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